Keppetipola
Research
Group
Role of Chemical Modifications in RNA Binding Protein and mRNA Processing
Our lab is interested in understanding how chemical modifications in RNA binding proteins play a role in regulating alternative splicing of premature messenger RNA transcripts and in turn, tissue specific gene expression patterns. We use the polypyrimidine tract binding protein family as a model system to carry out our studies. Two main research areas in the lab are to 1) understand the role of phosphate modifications and 2) the role of acetyl modifications in RNA binding protein function. We use a combination of molecular biology, biochemistry and cell biology techniques to carry out our studies.
Spring 2025 News:
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Issac Maldonado, John Baker, Gustavo Salgado and Chris Nunez presented their work at the annual CSUBIOTECH symposium this January!
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Manasvi, Johnny, Donald, and Angela have officially joined our group. Welcome!
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John's project "Determining How Two Similar Proteins Can Exert Different Functional Outcomes" was selected as a finalist for the 2025 CSUF-CSU Student Research Competition (SRC)! Congratulations John!