KEPPETIPOLA
RESEARCH
GROUP
Role of Chemical Modifications in RNA Binding Protein
and mRNA Processing
Our lab is interested in understanding how chemical modifications in RNA binding proteins play a role in regulating alternative splicing of premature messenger RNA transcripts and in turn, tissue specific gene expression patterns. We use the polypyrimidine tract binding protein family as a model system to carry out our studies. Two main research areas in the lab are to 1) understand the role of phosphate modifications and 2) the role of acetyl modifications in RNA binding protein function. We use a combination of molecular biology, biochemistry and cell biology techniques to carry out our studies.
Spring 2024 News:
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John received the Dr. Andrew and Kay Montana Endowed Scholarship in Chemistry and the Giles T Brown Thesis Support Award. Congratulations!
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Aline received the Glen and Takeshi Nakaya Scholarship. Congratulations!
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Dr. K received a Zhuangjie Li Research Award. Congratulations!
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Abby will be starting this fall in the Pharmacology PhD program at the Weill Cornell Graduate School of Medical Sciences. Congratulations, Abby!!
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Welcome to new members Edrin Astillero, Madelynn Perez, and Enzo Roldan.
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Welcome to new interns from Fullerton College, Samantha Hernandez and Antonio Alvarez
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Abby's abstract is selected for a talk at the National Council on Undergraduate Research this April. Congrats, Abby!
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Our paper on the role of unstructured regions in PTBP2 function is accepted to JBC! Click HERE to read!
