Our lab is interested in understanding how chemical modifications in RNA binding proteins play a role in regulating alternative splicing of premature messenger RNA transcripts and in turn, tissue specific gene expression patterns. We use the polypyrimidine tract binding protein family as a model system to carry out our studies. In our research about RNA binding protein function, we strive to understand these two areas:

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1) Role of phosphate modifications

2) Role of acetyl modifications

We use a combination of molecular biology, biochemistry and cell biology techniques to carry out our studies.